Basic and Clinical Sciences (BCSE) Practice Exam

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What anatomical change occurs in the lungs due to the smoking of tobacco?

  1. Hyperinflation of alveoli

  2. Peribronchial inflammation

  3. Thickened pleura

  4. Decreased lung volume

The correct answer is: Peribronchial inflammation

The choice of peribronchial inflammation as the correct answer is supported by the understanding of the pathological effects of tobacco smoking on the respiratory system. Smoking introduces numerous toxic substances into the lungs, triggering an inflammatory response. This inflammation primarily affects the airways, leading to swelling and irritation of the bronchi and bronchioles. Peribronchial inflammation refers to the inflammation that occurs in the connective tissue surrounding the bronchial tubes. This condition often leads to structural changes in the airways, increased mucus production, and can contribute to conditions such as chronic bronchitis. The inflammatory response is a significant factor in the development of related respiratory diseases in smokers. In contrast, while hyperinflation of alveoli may occur as a result of emphysema, the direct and immediate effect of tobacco smoking is more associated with inflammatory changes rather than hyperinflation. Thickened pleura may occur due to various other chronic lung conditions but not specifically as a direct consequence of smoking alone. Lastly, decreased lung volume is not characteristic of smoking in the early stages; rather, smoking typically leads to airflow obstruction and difficulties in expiration, which may give an impression of reduced lung capacity over time, but peribronchial inflammation is the more immediate and notable