Basic and Clinical Sciences (BCSE) Practice Exam

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What is an expected outcome of having both anatomical and physiological dead space in the lungs?

  1. Decreased overall ventilation efficiency

  2. Increased total lung capacity

  3. Improved oxygen transfer

  4. Enhanced carbon dioxide elimination

The correct answer is: Decreased overall ventilation efficiency

Having both anatomical and physiological dead space in the lungs is expected to lead to decreased overall ventilation efficiency. Anatomical dead space refers to the parts of the respiratory system where gas exchange does not occur, such as the trachea and bronchi. Physiological dead space includes both anatomical dead space and any areas of the lung that are well ventilated but poorly perfused, meaning that despite air reaching these areas, there is limited or no blood flow for gas exchange. When these dead spaces are present, a portion of the inhaled air does not participate in the process of gas exchange, which normally occurs in the alveoli. This inefficiency means that not all the inspired air contributes to oxygenating the blood or removing carbon dioxide effectively, leading to less efficient overall ventilation. This can impair respiratory function, especially in conditions such as chronic obstructive pulmonary disease (COPD) or other pulmonary conditions, where dead space may be increased. While it might seem that the total lung capacity could increase due to altered ventilation patterns or compensatory mechanisms, in reality, the increased volume of ineffective air limits overall efficiency rather than contributing positively to lung capacity. Similarly, improved oxygen transfer and enhanced carbon dioxide elimination are less likely to occur as a result of increased dead space,