Basic and Clinical Sciences (BCSE) Practice Exam

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What is the duration of treatment for childhood miliary tuberculosis and TB meningitis?

  1. 3-6 months

  2. 6-12 months

  3. 12-18 months

  4. 1-2 years

The correct answer is: 6-12 months

The appropriate duration of treatment for childhood miliary tuberculosis and TB meningitis is generally 6-12 months. This time frame is supported by clinical guidelines that emphasize the need for prolonged therapy due to the severity and potential complications associated with these forms of tuberculosis. Miliary tuberculosis involves the dissemination of Mycobacterium tuberculosis throughout the body, leading to a widespread infection that requires adequate time to ensure complete resolution and prevent relapses. Similarly, TB meningitis is a serious central nervous system infection that not only demands effective treatment of the tuberculosis infection but also addresses possible complications, such as neurological sequelae. To maximize treatment effectiveness and minimize the risk of drug resistance, adherence to the recommended duration of therapy is crucial. In contrast, shorter durations of 3-6 months would generally apply to less disseminated forms of tuberculosis that do not require the same level of intensive and prolonged treatment. Likewise, durations longer than 12 months may be unnecessary for these specific conditions unless complicated by other factors.