Basic and Clinical Sciences (BCSE) Practice Exam

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What type of tissue change is commonly observed in leukocytoclastic vasculitis?

  1. Necrosis

  2. Hyperplasia

  3. Vasculitis

  4. Ischemia

The correct answer is: Vasculitis

Leukocytoclastic vasculitis is characterized primarily by the presence of inflammation in small blood vessels, often leading to noticeable tissue changes. The hallmark of this condition is the infiltration of neutrophils and subsequent damage to the blood vessel walls, which is indicative of vasculitis. The term "vasculitis" itself refers directly to the inflammation of blood vessels, which is a key feature in leukocytoclastic vasculitis. This process results in necrosis and other tissue changes due to the inflammatory response, but the underlying issue is the vasculitis itself. Thus, identifying "vasculitis" as the type of tissue change focuses on the inflammation affecting the vessels, which can lead to subsequent complications such as necrosis, but which stems from the inflammatory process that defines the condition. In this context, while necrosis may occur as a result of the tissue damage from the inflammatory process, hyperplasia and ischemia are not primary features associated with leukocytoclastic vasculitis specifically. Hyperplasia refers to an increase in cell numbers typically due to a stimulus leading to proliferation, which isn't the main process in leukocytoclastic vasculitis. Ischemia denotes a lack of blood supply, which can arise secondary to the