Basic and Clinical Sciences (BCSE) Practice Exam

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Which condition can lead to hypovolemic hyponatremia?

  1. Hyperaldosteronism

  2. Chronic renal failure

  3. Diuretics usage

  4. Heart failure

The correct answer is: Diuretics usage

Hypovolemic hyponatremia occurs when there is a depletion of intravascular volume (hypovolemia) coupled with a low sodium concentration (hyponatremia). One of the most common causes of hypovolemic hyponatremia is the use of diuretics. Diuretics promote increased urine output, which can lead to the loss of both water and electrolytes, including sodium. If there is significant sodium loss and the body’s capacity to compensate with appropriate hormonal responses is overwhelmed, the sodium concentration in the blood can drop, leading to hyponatremia. This is especially true in cases of excessive or prolonged diuretic use, where the individual may not be adequately replacing lost fluids or salts. In contrast, conditions like hyperaldosteronism typically lead to hypernatremia due to increased retention of sodium. Chronic renal failure can result in a different fluid and electrolyte balance but does not directly cause hypovolemic hyponatremia; it may cause a different form of hyponatremia due to fluid retention or dilution. Heart failure is more often associated with euvolemic or hypervolemic states, again making hypovolemic hyponatrem