Basic and Clinical Sciences (BCSE) Practice Exam

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Which condition is primarily due to impaired diffusion?

  1. Histotoxic hypoxia

  2. Hypoxic hypoxia

  3. Stagnant hypoxia

  4. Hypoxemic respiratory failure

The correct answer is: Hypoxemic respiratory failure

The correct answer, which centers around hypoxemic respiratory failure, highlights a condition characterized by a deficiency of oxygen in the arterial blood caused primarily by impaired diffusion, among other potential mechanisms. Hypoxemic respiratory failure occurs when there is insufficient oxygenation of the blood, typically due to inadequate diffusion of oxygen across the alveolar-capillary membrane in the lungs. This impaired diffusion can stem from conditions that affect the lung tissue, such as pulmonary edema, interstitial lung diseases, or pneumonia, where the increased distance or fluid accumulation interferes with the efficient transfer of oxygen from the alveoli into the bloodstream. In this context, while other types of hypoxia also exist, they refer to different mechanisms. For instance, histotoxic hypoxia occurs when cells are unable to utilize oxygen effectively, as seen in conditions like cyanide poisoning. Hypoxic hypoxia refers to low partial pressures of oxygen in the atmosphere leading to insufficient oxygen available for respiration, particularly notable at high altitudes. Stagnant hypoxia relates to decreased blood flow, such as in cases of shock or heart failure, which doesn't directly pertain to diffusion issues. Thus, hypoxemic respiratory failure is primarily linked with problems in oxygen transfer due to diffusion impairments in the lungs, making