Basic and Clinical Sciences (BCSE) Practice Exam

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Which term describes the loss of water exceeding sodium loss?

  1. Hypervolemic hypernatremia

  2. Hypovolemic hypernatremia

  3. Euvolemic hypernatremia

  4. Hypovolemic hyponatremia

The correct answer is: Hypovolemic hypernatremia

The correct term for the loss of water exceeding sodium loss is hypovolemic hypernatremia. This condition typically occurs when there is a deficit of total body water relative to sodium. When water loss occurs without corresponding sodium loss, the sodium concentration in the blood increases, leading to hypernatremia. Hypovolemic hypernatremia often arises from conditions such as severe dehydration, excessive sweating, or renal losses, where the body loses more fluid than it retains. This scenario results in both a decrease in overall fluid volume (hypovolemia) and an increase in serum sodium levels. The other terms do not accurately describe this condition. Hypervolemic hypernatremia indicates an increased volume of fluid along with elevated sodium levels, typically due to conditions like saline overload or mineralocorticoid excess. Euvolemic hypernatremia reflects a normal fluid volume despite elevated sodium levels, often seen in situations of insensible water loss or diabetes insipidus. Hypovolemic hyponatremia would suggest a decrease in sodium concentration due to excess water retention relative to sodium, which is the opposite of what occurs in hypovolemic hypernatremia.